John Kerry will meet with German Foreign Minister Frank-Walter Steinmeier in Moscow on Wednesday, Radio Free Europe reports.
He will also hold talks with Russian President Vladimir Putin and Foreign Minister Sergei Lavrov on March 24.
During the visit, Kerry is expected to gauge whether the Russian leadership is ready to discuss ways to ease Syrian President Bashar al-Assad from power.
On Ukraine, he is expected to call on Moscow to do more to press Russian-backed separatists in the country’s east to comply with a cease-fire.
He is also due to raise the case of Ukrainian military pilot Nadia Savchenko, who was sentenced to 22 years in prison in Russia for her alleged involvement in the death of two Russian journalists in eastern Ukraine.
Washington has repeatedly called for Savchenko to be released.